Description

Ethionamide-D3 is a deuterated isotopologue of the second-line anti-tuberculosis agent Ethionamide, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in advanced bioanalytical method development and drug metabolism research for tuberculosis treatments.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of Ethionamide in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in DMPK studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Ethionamide, improving data accuracy through isotope dilution.
• Bioanalytical Method Development: Essential for developing and validating robust, GLP-compliant analytical methods for therapeutic drug monitoring and clinical trial sample analysis.
• Metabolite Identification and Profiling: Aids in the identification and quantification of drug metabolites, facilitating a deeper understanding of Ethionamide's metabolic pathways.
• Pharmaceutical Quality Control: Can be utilized in advanced quality control laboratories for method verification and ensuring the specificity of analytical procedures.

Basic Information

Product Name	Ethionamide-D3
CAS No.	2748267-66-3
Molecular Formula	C8H7D3N2S
Molecular Weight	169.24 g/mol (for C8H7D3N2S)
Synonyms	2-Ethylpyridine-4-carbothioamide-D3; 2-Ethylisonicotinothioamide-D3; Ethionamide (phenyl-D3); Trecator-D3; 2-Ethyl-4-pyridinecarbothioamide-D3; α-Ethyl-isonicotinthioamide-D3; 4-Pyridinecarbothioamide, 2-ethyl-, D3-labeled; Deuterated Ethionamide Internal Standard
EINECS	Contact for details

Quality Control

Our Ethionamide-D3 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (e.g., D3 ≥ 99%), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We ensure compliance with the high standards expected in pharmaceutical and analytical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.