Description

Bosutinib-D8 is a deuterated isotopologue of the tyrosine kinase inhibitor Bosutinib, specifically labeled with eight deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise and accurate quantification of Bosutinib in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Primary use as an internal standard for the quantitative bioanalysis of Bosutinib in plasma, serum, and tissue samples.
• Critical component in LC-MS/MS method development and validation for clinical and preclinical studies.
• Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) profiling of Bosutinib in drug development pipelines.
• Enables reliable drug metabolism and excretion (DMPK) studies by correcting for matrix effects and instrument variability.
• Supports therapeutic drug monitoring (TDM) research to optimize dosing regimens.
• Used in academic research investigating the mechanisms and resistance pathways of Bcr-Abl tyrosine kinase inhibition.

Basic Information

Product Name	Bosutinib-D8
CAS No.	2733145-45-2
Molecular Formula	C₂₆H₂₁D₈Cl₂N₅O₃
Molecular Weight	530.48 g/mol (approx.)
Synonyms	Bosutinib (phenyl-d5,3,5-d2,chloro-d)-d8; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl-d8)propoxy]-3-quinolinecarbonitrile; SKI-606-d8; Bosutinib-d8; Deuterated Bosutinib; Bosutinib Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Bosutinib-D8 is manufactured and analyzed under strict quality protocols to ensure the highest isotopic purity and chemical integrity required for sensitive bioanalytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (≥98% D), chemical purity (by HPLC), and structural confirmation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.