Description

Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4R,5R)- is a sophisticated chiral ligand and a key building block in advanced chemical synthesis. Its value lies in its unique structure, combining an oxazoline ring with a phosphine group, which makes it highly effective for creating stereoselective environments in transition metal catalysis. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries who require precise control over asymmetric reactions, such as hydrogenations and cross-couplings, to produce enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Catalysis: As a chiral bidentate ligand for transition metals like rhodium, iridium, and palladium in enantioselective hydrogenation and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: For the production of chiral drug candidates and APIs where high enantiomeric purity is critical for efficacy and safety.
• Fine Chemical Manufacturing: Used in the synthesis of complex, high-value specialty chemicals, including flavors, fragrances, and agrochemicals.
• Academic and Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways in organic chemistry.
• Material Science Research: Potential applications in the development of chiral polymers or as a component in advanced molecular recognition systems.

Basic Information

Product Name	Oxazole, 2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-4,5-Diphenyl-, (4R,5R)-
CAS No.	2680585-79-7
Molecular Formula	C39H30NOP
Molecular Weight	559.64 g/mol
Synonyms	(4R,5R)-2-[2-(Diphenylphosphino)phenyl]-4,5-diphenyl-4,5-dihydrooxazole; (R,R)-2-[2-(Diphenylphosphino)phenyl]-4,5-diphenyl-2-oxazoline; (R,R)-Ph-Phox; Chiral Ph-Phox Ligand; (4R,5R)-4,5-Diphenyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; P,N-Ligand; Chiral Oxazoline-Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our (4R,5R)-Ph-Phox ligand is produced and tested under strict quality management protocols to ensure exceptional purity and chiral integrity, critical for high-performance catalysis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and identity confirmation. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and light-sensitive; prolonged exposure to air or light may degrade its catalytic performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.