Description

(4S,4'S)-2,2'-(2-(4-(tert-Butyl)Phenyl)Ethane-1,1-Diyl)Bis(4-(tert-Butyl)-4,5-Dihydrooxazole) CAS NO 2634687-80-0 is a high-purity, chiral bis(oxazoline) ligand, a critical class of compounds in asymmetric synthesis. Its value lies in its ability to act as a highly effective and selective catalyst or ligand in metal-catalyzed reactions, enabling the production of enantiomerically pure intermediates. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Asymmetric Catalysis: Serving as a privileged chiral ligand for a wide range of metal-catalyzed reactions including Diels-Alder, cyclopropanation, and aldol reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the enantioselective synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Facilitating the creation of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Fine Chemical Manufacturing: Used in the production of specialty chemicals, flavors, and fragrances where optical purity is paramount.
• Academic & Industrial R&D: A key tool for methodology development in organic synthesis and catalysis research.
• Material Science: Potential application in the synthesis of chiral polymers and advanced functional materials.

Basic Information

Product Name	(4S,4'S)-2,2'-(2-(4-(tert-Butyl)Phenyl)Ethane-1,1-Diyl)Bis(4-(tert-Butyl)-4,5-Dihydrooxazole)
CAS No.	2634687-80-0
Molecular Formula	C34H48N2O2
Molecular Weight	516.76 g/mol
Synonyms	(S,S)-t-Bu-Phenyl-BOX Ligand; (S,S)-tert-Butyl-Phenyl-Bis(oxazoline); (4S,4'S)-Di-tert-butyl-2,2'-(2-(4-tert-butylphenyl)ethane-1,1-diyl)bis(4,5-dihydrooxazole); Chiral BOX Ligand; (S,S)-Phenyl-Bisoxazoline Ligand; Asymmetric Bis(oxazoline) Ligand; tBu-Ph-BOX
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for reproducible catalytic performance. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.