Description

(S)-4-((S)-sec-Butyl)-2-(2-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole is a highly specialized, chiral phosphine-oxazoline (PHOX) ligand, a critical class of organocatalysts in asymmetric synthesis. Its value lies in enabling precise stereochemical control in transition metal-catalyzed reactions, which is paramount for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-performance ligands for cross-coupling, hydrogenation, and other asymmetric transformations.

Application

• As a chiral ligand in asymmetric transition metal catalysis, such as rhodium- or iridium-catalyzed hydrogenations.
• For enantioselective synthesis of key pharmaceutical intermediates, including active pharmaceutical ingredients (APIs).
• In asymmetric C-C bond-forming reactions like Heck, Suzuki-Miyaura, and allylic alkylation.
• As a critical component in catalyst screening libraries for process research and development.
• For the development of stereoselective polymerization catalysts in advanced polymer science.
• In academic and industrial research focused on novel catalytic methodologies.

Basic Information

Product Name	(S)-4-((S)-sec-Butyl)-2-(2-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole
CAS No.	2634687-75-3
Molecular Formula	C27H30NOP
Molecular Weight	415.51 g/mol
Synonyms	(S,S)-t-Bu-PHOX; (S)-4-[(1S)-1-Methylpropyl]-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-1,3-oxazole; (S,S)-tert-ButylPHOX; (S,S)-sec-ButylPHOX Ligand; PHOX Ligand, (S,S)-t-Bu; Chiral PHOX Ligand; Oxazoline Phosphine Ligand
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to stringent quality assurance protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with your research or cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity, keep away from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.