Description

(R)-4-Benzyl-2-(2-Chloro-6-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole is a chiral, P,N-bidentate ligand, a crucial class of organocatalysts and auxiliaries in modern synthetic chemistry. This compound matters for its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of optically pure intermediates essential for advanced materials and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for asymmetric synthesis, including hydrogenation, cross-coupling, and hydroformylation reactions.

Application

• As a chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• Catalyst component in enantioselective cross-coupling reactions (e.g., Suzuki-Miyaura, Heck).
• Use in asymmetric hydroformylation to create chiral aldehydes.
• Key auxiliary in the synthesis of enantiomerically pure agrochemicals.
• Research and development of novel catalytic systems in academic and industrial laboratories.
• Production of specialty fine chemicals and advanced materials requiring high optical purity.

Basic Information

Product Name	(R)-4-Benzyl-2-(2-Chloro-6-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole
CAS No.	2634687-74-2
Molecular Formula	C28H23ClNOP
Molecular Weight	455.91 g/mol
Synonyms	(R)-4-Benzyl-2-(2-chloro-6-(diphenylphosphanyl)phenyl)-4,5-dihydro-1,3-oxazole; (R)-2-(2-Chloro-6-(diphenylphosphino)phenyl)-4-benzyl-4,5-dihydrooxazole; (R)-Cl-BozPhos; (R)-BozPhos derivative; Chiral oxazoline-phosphine ligand; P,N-Ligand; (R)-Benzyl-BozPhos; Asymmetric bidentate ligand
EINECS	Contact for details

Quality Control

Our (R)-4-Benzyl-2-(2-Chloro-6-(Diphenylphosphino)Phenyl)-4,5-Dihydrooxazole is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Each lot is characterized by NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing purity, chiral purity, and full analytical data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep the container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.