Description

(S)-4-Cyclohexyl-2-(2-(Diphenylphosphanyl)Phenyl)-4,5-Dihydrooxazole is a chiral, P,N-bidentate ligand belonging to the oxazoline class, widely recognized for its efficacy in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, crucial for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This high-purity ligand is essential for research institutions and industrial manufacturers developing advanced chiral compounds, particularly in the areas of asymmetric hydrogenation, hydroformylation, and cross-coupling reactions.

Application

The primary application of this specialized ligand is as a catalyst component in asymmetric synthesis. Key use cases include:

• Asymmetric Hydrogenation: For the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Asymmetric Hydroformylation: In the synthesis of chiral aldehydes from olefins, which are valuable pharmaceutical building blocks.
• Cross-Coupling Reactions: As a supporting ligand in palladium-catalyzed reactions like Suzuki-Miyaura and Heck couplings to control stereochemistry.
• Pharmaceutical Intermediate Synthesis: For the production of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.
• Academic & Industrial R&D: As a critical tool for methodology development in organic and organometallic chemistry.
• Fine Chemical Manufacturing: In the synthesis of specialty chemicals, flavors, and fragrances requiring high optical purity.

Basic Information

Item	Information
Product Name	(S)-4-Cyclohexyl-2-(2-(Diphenylphosphanyl)Phenyl)-4,5-Dihydrooxazole
CAS No.	2634687-58-2
Molecular Formula	C27H28NOP
Molecular Weight	413.49 g/mol
Synonyms	(S)-CyHex-PHOX; (S)-4-Cyclohexyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (S)-2-(2-(Diphenylphosphino)phenyl)-4-cyclohexyl-4,5-dihydrooxazole; (S)-PHOX Ligand (Cyclohexyl variant); P,N-Ligand; Chiral Oxazoline-Phosphine Ligand; Josiphos-type ligand analog; Asymmetric Catalysis Ligand
EINECS	Contact for details

Quality Control

Our production of (S)-4-Cyclohexyl-2-(2-(Diphenylphosphanyl)Phenyl)-4,5-Dihydrooxazole adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Each lot is characterized using advanced analytical techniques, including Chiral HPLC, NMR spectroscopy, and elemental analysis. Comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and identity are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (argon or nitrogen) in a freezer (-20°C) is recommended to maintain optimal stability and performance. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.