Description

(6R,7S)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Methoxyimino)Acetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate, specifically a cephalosporin nucleus derivative. This compound is critical for the synthesis of modern, broad-spectrum β-lactam antibiotics, offering a key building block for enhanced efficacy and stability. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Core intermediate for the production of third and fourth-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for designing and testing novel antibacterial compounds with improved resistance profiles.
• Process Chemistry: Serves as a key starting material (KSM) or intermediate in scalable GMP manufacturing processes for final drug substances.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing of cephalosporin-based drugs.
• Antibacterial Agent Development: Fundamental component for creating derivatives aimed at combating multi-drug resistant bacterial infections.

Basic Information

Product Name	(6R,7S)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Methoxyimino)Acetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
CAS No.	2630907-20-7
Molecular Formula	C14H14N6O5S2
Molecular Weight	410.42 g/mol
Synonyms	7-ACA Aminothiazole Methoxyimino Derivative; (6R,7S)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cephalosporin C-7 Side Chain Intermediate; ATMA Intermediate; 7-ATMA; 7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]cephalosporanic Acid; Aminothiazolyl Methoxyimino Acetamido Cephalosporanic Acid
EINECS	Contact for details

Quality Control

Our (6R,7S)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Methoxyimino)Acetamido)-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your regulatory and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. Ensure the storage area is well-ventilated and separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (6R,7S isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.