Description

Dbco-Peg3-Oh is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry and a terminal hydroxyl group for further functionalization. This compound is essential for creating stable, bioconjugate structures without the need for cytotoxic copper catalysts, making it ideal for sensitive biological applications. It is primarily used by researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced materials science for constructing antibody-drug conjugates (ADCs), PEGylated therapeutics, and diagnostic probes.

Application

• Bioconjugation and ADC Development: Serves as a key linker for site-specific conjugation of cytotoxic drugs to monoclonal antibodies via copper-free click chemistry.
• PEGylation Reagent: Used to introduce hydrophilic PEG spacers onto peptides, proteins, or nanoparticles to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Synthesis: Facilitates the labeling of biomolecules (e.g., antibodies, oligonucleotides) with fluorescent dyes or other reporter molecules for imaging and detection.
• Hydrogel and Biomaterial Fabrication: Acts as a crosslinking agent or functional building block in the creation of biocompatible scaffolds for tissue engineering and drug delivery systems.
• Surface Functionalization: Enables the modification of sensor chips, microarrays, and other solid surfaces with biomolecules for biosensing applications.
• Chemical Biology Tool: Employed in proteomics and glycomics research for tagging and enriching azide-labeled biomolecules.

Basic Information

Product Name	Dbco-Peg3-Oh
CAS No.	2566404-76-8
Molecular Formula	C₂₈H₃₃NO₆
Molecular Weight	479.57 g/mol
Synonyms	DBCO-PEG3-OH; DBCO-PEG3-Alcohol; Dibenzocyclooctyne-PEG3-OH; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl)carbamate; 1-(2-{2-[2-(2-{[(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethoxy]carbonylamino}ethoxy)ethoxy]ethoxy}ethanol; Azadibenzocyclooctyne-PEG3-OH; ADIBO-PEG3-OH
EINECS	Contact for details

Quality Control

Our Dbco-Peg3-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) detailing purity, identity, and other relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.