Description

[S(R)]-n-[(R)-3,5-Bis(Trifluoromethyl)Phenyl][2-(Dicyclohexylphosphanyl)Phenyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in modern asymmetric synthesis. Its value lies in enabling highly enantioselective transition metal-catalyzed reactions, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to optimize stereochemical control.

Application

• Asymmetric Hydrogenation: A key ligand for rhodium or ruthenium catalysts in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including antiviral and anticancer agents.
• Cross-Coupling Reactions: Used in palladium-catalyzed asymmetric cross-couplings (e.g., Suzuki-Miyaura, Buchwald-Hartwig) to form C-C and C-N bonds with high enantiopurity.
• Agrochemical Production: Enables the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and process chemistry groups.
• Catalyst Screening Libraries: Serves as a high-value component in catalyst libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	[S(R)]-n-[(R)-3,5-Bis(Trifluoromethyl)Phenyl][2-(Dicyclohexylphosphanyl)Phenyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-86-9
Molecular Formula	C₃₁H₃₈F₆NOPS
Molecular Weight	609.67 g/mol
Synonyms	(S,R)-Josiphos-type Sulfinamide Ligand; (S,R)-SF-Phos; N-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropyl]-S-phenyl-S-(2-dicyclohexylphosphanyl-phenyl)-N-methylsulfinimidic amide; Chiral Sulfinyl Phosphine Ligand; Asymmetric Hydrogenation Ligand 2565792-86-9
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced under strict quality control in a GMP-compliant environment to ensure exceptional purity and enantiomeric excess (ee) for critical asymmetric transformations. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (HPLC), elemental analysis, and spectroscopic identity (NMR). Our quality system is designed to meet the stringent requirements of pharmaceutical development and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool place. This compound is easily oxidized and sensitive to strong bases; ensure the container is sealed immediately after use to exclude moisture and oxygen. For long-term storage, keep the primary container within a sealed secondary container with desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.