Description

[S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-[2-(Dicyclohexylphosphanyl)Phenyl]Ethyl]-2-Methyl-2-Propanesulfinamide is a sophisticated, chiral sulfinamide-phosphine hybrid ligand designed for high-performance asymmetric catalysis. This compound matters because it enables the precise control of stereochemistry in critical bond-forming reactions, leading to higher yields and enantiomeric purity of target molecules. It is essential for R&D chemists and process engineers in the pharmaceutical and fine chemical industries developing novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• As a privileged chiral ligand in asymmetric hydrogenation and other transition metal-catalyzed reactions.
• For the synthesis of enantiomerically pure pharmaceutical intermediates, including β-amino acids and amines.
• In academic and industrial research for developing new catalytic methodologies.
• As a key component in catalyst systems for the production of agrochemicals and specialty chemicals.
• For process optimization in scaling up asymmetric syntheses from laboratory to pilot plant.

Basic Information

Product Name	[S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-[2-(Dicyclohexylphosphanyl)Phenyl]Ethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-85-8
Molecular Formula	C₃₉H₅₀NO₂P₂S
Molecular Weight	674.82 g/mol
Synonyms	(S)-N-[(1S)-2-(Diphenylphosphino)-1-[2-(dicyclohexylphosphanyl)phenyl]ethyl]-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1S)-2-(diphenylphosphino)-1-[2-(dicyclohexylphosphino)phenyl]ethyl]-; Sulfinamide-phosphine ligand; Chiral Josiphos-type sulfinamide ligand; Asymmetric hydrogenation ligand; CAS 2565792-85-8
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and performance consistency. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (by HPLC/NMR), and chiral purity. Our quality systems support development under cGMP guidelines for pharmaceutical applications, and we comply with relevant global chemical regulations including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.