Description

[S(R)]-n-[(R)-[6-(Diphenylphosphino)Benzo[D][1,3]Dioxol-5-Yl]Phenylmethyl]-2-Methyl-2-Propanesulfinamide is a highly specialized chiral sulfinamide-phosphine hybrid ligand, a key building block in asymmetric synthesis. This compound matters for its ability to induce high enantioselectivity in critical transition-metal catalyzed reactions, enabling the production of single-enantiomer pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and complex molecular architectures.

Application

• Asymmetric Catalysis: As a privileged ligand for palladium, rhodium, and iridium complexes in cross-coupling, hydrogenation, and hydroformylation reactions.
• Pharmaceutical Intermediate Synthesis: For the enantioselective construction of chiral centers in drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: In the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Development: Used by academic and industrial chemists to discover and optimize new catalytic asymmetric transformations.
• Fine Chemical Production: Enabling the commercial-scale synthesis of specialty chemicals and flavors & fragrances with high optical purity.
• Material Science: Potential application in the synthesis of chiral polymers or metal-organic frameworks (MOFs) with specific asymmetric properties.

Basic Information

Item	Details
Product Name	[S(R)]-n-[(R)-[6-(Diphenylphosphino)Benzo[D][1,3]Dioxol-5-Yl]Phenylmethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-84-7
Molecular Formula	C30H28NO3PS
Molecular Weight	513.58 g/mol
Synonyms	(R)-2-Methyl-2-propanesulfinamide, N-[(1R)-1-[6-(Diphenylphosphino)-1,3-benzodioxol-5-yl]phenylmethyl]-; (R)-N-((R)-1-(6-(Diphenylphosphino)benzo[d][1,3]dioxol-5-yl)phenyl)methyl)-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; Sulfinyl Phosphine Ligand; Asymmetric Catalyst Ligand; (R,R)-Sulfinamide-Diphenylphosphino-Benzodioxole Ligand; CAS 2565792-84-7
EINECS	Contact for details

Quality Control

Our production of [S(R)]-n-[(R)-[6-(Diphenylphosphino)Benzo[D][1,3]Dioxol-5-Yl]Phenylmethyl]-2-Methyl-2-Propanesulfinamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric excess (ee). Each lot is characterized by NMR (1H, 13C, 31P), HPLC, and specific rotation analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment, supporting cGMP and ISO 9001 compliant workflows for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. Due to its sensitivity, allow the container to reach room temperature before opening to minimize moisture condensation and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.