Description

[S(R)]-n-[(S)-[2-(Dicyclohexylphosphanyl)Phenyl](4-Methoxyphenyl)Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in modern asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in critical transition-metal catalyzed reactions, enabling the production of single-enantiomer compounds with superior efficiency. This advanced intermediate is essential for research and development chemists and process scientists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel active ingredients and high-value specialty molecules.

Application

• Asymmetric Catalysis: As a privileged ligand for palladium, rhodium, and iridium complexes in cross-coupling, hydrogenation, and hydroformylation reactions.
• Pharmaceutical Intermediate Synthesis: For the enantioselective construction of chiral centers in drug candidates, including APIs for oncology, CNS, and cardiovascular therapies.
• Agrochemical Development: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Research: As a benchmark ligand in academic and industrial R&D for developing new catalytic asymmetric transformations.
• Process Chemistry Optimization: Scaling up asymmetric synthetic routes from laboratory to pilot plant and commercial production.
• Fine Chemical Manufacturing: Production of chiral flavors, fragrances, and advanced materials requiring high optical purity.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Dicyclohexylphosphanyl)Phenyl](4-Methoxyphenyl)Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-82-5
Molecular Formula	C31H46NO2PS
Molecular Weight	527.73 g/mol
Synonyms	(S)-N-[(S)-(2-(Dicyclohexylphosphino)phenyl)(4-methoxyphenyl)methyl]-2-methylpropane-2-sulfinamide; (S)-N-[(S)-(2-(Dicyclohexylphosphanyl)phenyl)(4-methoxyphenyl)methyl]-2-methylpropane-2-sulfinamide; Sulfinamide-phosphine hybrid ligand; Chiral sulfinamide phosphine ligand; Josiphos-type sulfinamide ligand; Asymmetric synthesis ligand; CAS 2565792-82-5
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation is provided with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.