Description

[S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a pinnacle of modern asymmetric synthesis toolkits. This compound matters for its exceptional ability to induce high enantioselectivity in transition-metal catalyzed reactions, enabling the efficient production of single-enantiomer intermediates critical for advanced pharmaceuticals. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other high-value chiral molecules where stereochemical purity is paramount.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing stereogenic centers in complex drug candidates, including those for oncology, CNS disorders, and cardiovascular diseases.
• Agrochemical Development: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions.
• Academic & Process Chemistry Research: A valuable tool for methodology development and exploring new catalytic asymmetric transformations.
• Catalyst Library Development: Serves as a high-performance component in screening libraries for discovering new catalytic processes.

Basic Information

Product Name	[S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-75-6
Molecular Formula	C38H58NO2PS
Molecular Weight	623.91 g/mol
Synonyms	(SR,R)-DTBM-SEGPHOS Sulfinamide; (R)-DTBM-SEGPHOS-Based Sulfinamide Ligand; (SR,R)-[2-(Dicyclohexylphosphino)phenyl][3,5-di-tert-butyl-4-methoxyphenyl]methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinyl Phosphine Ligand; Asymmetric Sulfinamide-Phosphine Hybrid Ligand; CAS 2565792-75-6; DTBM-SEGPHOS-Sulfinamide
EINECS	Contact for details

Quality Control

Our [S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, NMR (1H, 13C, 31P), and mass spectrometry, to ensure high chemical and enantiomeric purity suitable for sensitive catalytic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.