Description

[S(R)]-n-[(S)-[3,5-Bis(Trifluoromethyl)Phenyl][2-(Diphenylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in modern asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity chiral auxiliaries and ligands.

Application

• As a chiral ligand in asymmetric hydrogenation, hydroformylation, and cross-coupling reactions.
• Critical component in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and drug intermediates.
• Use in the development of novel asymmetric catalysts for academic and industrial research.
• Production of high-value agrochemicals and flavors & fragrances requiring specific stereochemistry.
• As a sulfinamide auxiliary in diastereoselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Key reagent for process chemistry optimization in scale-up campaigns for chiral molecules.

Basic Information

Product Name	[S(R)]-n-[(S)-[3,5-Bis(Trifluoromethyl)Phenyl][2-(Diphenylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-74-5
Molecular Formula	C32H30F6NOPS
Molecular Weight	621.62 g/mol
Synonyms	(SR)-N-[(S)-[3,5-Bis(trifluoromethyl)phenyl][2-(diphenylphosphino)phenyl]methyl]-N,2-dimethylpropane-2-sulfinamide; (SR)-N-[(S)-[3,5-Bis(trifluoromethyl)phenyl][2-(diphenylphosphino)phenyl]methyl]-N,2-dimethyl-2-propanesulfinamide; Chiral Sulfinamide-Phosphine Ligand; (SR,S)-Sulfinamide-Phosphine Hybrid Ligand; (SR)-N-[(S)-[3,5-Bis(trifluoromethyl)phenyl][2-(diphenylphosphanyl)phenyl]methyl]-N,2-dimethylpropane-2-sulfinamide; (SR)-N-[(S)-[3,5-Bis(trifluoromethyl)phenyl][2-(diphenylphosphanyl)phenyl]methyl]-N,2-dimethyl-2-propanesulfinamide; CAS 2565792-74-5
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to stringent quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.