Description

[S(R)]-n-[(R)-[2-(Dicyclohexylphosphino)Phenyl]-2-Naphthalenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for the efficient synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This advanced ligand is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in metal-catalyzed reactions such as cross-couplings and hydrogenations.

Application

• As a chiral ligand in asymmetric metal-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig).
• For enantioselective hydrogenation of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• In the development of asymmetric C-H activation and functionalization methodologies.
• As a key component in catalyst screening kits for high-throughput experimentation (HTE) in drug discovery.
• For the synthesis of optically pure natural products and complex molecular architectures.
• In academic and industrial research focused on novel catalytic cycles and mechanism elucidation.

Basic Information

Product Name	[S(R)]-n-[(R)-[2-(Dicyclohexylphosphino)Phenyl]-2-Naphthalenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-68-7
Molecular Formula	C34H44NOPS
Molecular Weight	545.75 g/mol
Synonyms	(SR)-N-[(R)-[2-(Dicyclohexylphosphino)phenyl](naphthalen-2-yl)methyl]-N,2-dimethylpropane-2-sulfinamide; (SR)-N-[(R)-[2-(Dicyclohexylphosphino)phenyl](2-naphthyl)methyl]-N,2-dimethyl-2-propanesulfinamide; Chiral Sulfinamide-Phosphine Ligand; Asymmetric DCPP-Sulfinamide Ligand; Hybrid P,N,S-Ligand; (R)-[2-(Dicyclohexylphosphino)phenyl]-2-naphthalenylmethyl (SR)-N,2-Dimethyl-2-propanesulfinamide
EINECS	Contact for details

Quality Control

Our high-value chiral ligands are produced and handled under strict quality-controlled conditions to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes comprehensive analysis including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool environment. For long-term storage, keep desiccated at -20°C. Allow the container to reach room temperature in a dry atmosphere before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.