Description

[S(R)]-n-[(S)-[(3-(Benzyloxy)-2-(Dicyclohexylphosphino)Phenyl)Phenylmethyl]-2-Methyl-2-Propanesulfinamide CAS NO 2565792-64-3 is a sophisticated chiral sulfinamide-phosphine hybrid ligand, designed for high-performance asymmetric catalysis. This compound matters because it enables precise stereochemical control in critical bond-forming reactions, directly impacting the efficiency and purity of advanced pharmaceutical intermediates. It is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-selectivity catalysts for complex synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug molecules, including antivirals, oncology treatments, and cardiovascular agents.
• Agrochemical Active Ingredient Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new asymmetric transformations in process chemistry.
• Catalyst Library Development: Serves as a high-value component in proprietary catalyst libraries for contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	[S(R)]-n-[(S)-[(3-(Benzyloxy)-2-(Dicyclohexylphosphino)Phenyl)Phenylmethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-64-3
Molecular Formula	C39H52NO2PS
Molecular Weight	629.87 g/mol
Synonyms	(S)-N-((S)-(3-(Benzyloxy)-2-(dicyclohexylphosphino)phenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1S)-1-[3-(phenylmethoxy)-2-(dicyclohexylphosphino)phenyl]-1-phenylethyl]-; Chiral Sulfinamide-Phosphine Ligand; Dicyclohexylphosphino-Benzyloxy-Phenyl-Sulfinamide Ligand; Asymmetric Hydrogenation Ligand; P,N-Ligand; Sulfinyl Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management systems. We guarantee high chemical and chiral purity through advanced analytical techniques including HPLC, NMR, and chiral chromatography. A comprehensive Certificate of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profile is provided with each shipment to ensure compliance with your R&D and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or ambient temperature should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.