Description

[S(R)]-n-[(S)-[2-(Di-tert-Butylphosphino)Phenyl[(2-Naphthalenyl)Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated, chiral sulfinamide-phosphine hybrid ligand designed for asymmetric catalysis. This compound matters because it enables highly enantioselective transformations, critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals with superior purity and efficacy. It is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in metal-catalyzed reactions such as cross-couplings and hydrogenations.

Application

• As a chiral ligand in asymmetric transition metal catalysis, including palladium-catalyzed cross-coupling reactions.
• For the enantioselective synthesis of pharmaceutical intermediates and active ingredients (APIs) requiring high optical purity.
• In the development of novel agrochemicals and flavors/fragrances where stereochemistry impacts biological activity.
• As a key component in academic and industrial research for method development in organic synthesis.
• For process chemistry optimization in scaling up the production of chiral molecules.
• In catalyst screening libraries for discovering new asymmetric transformations.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Di-tert-Butylphosphino)Phenyl[(2-Naphthalenyl)Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-62-1
Molecular Formula	C30H40NOPS
Molecular Weight	493.69 g/mol
Synonyms	(SR)-N-[(S)-[2-(Di-tert-butylphosphino)phenyl](naphthalen-2-yl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-[2-(Di-tert-butylphosphino)phenyl](2-naphthyl)methyl]-2-methylpropane-2-sulfinamide; Sulfinamide-phosphine ligand; Chiral P,N-ligand; tert-Butylsulfinamide-phosphine ligand; (SR,S)-DTBM-SEGPHOS sulfinamide variant; Asymmetric catalyst ligand 2565792-62-1.
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and analyzed under strict quality control protocols to ensure identity, purity, and enantiomeric excess. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for HPLC purity, chiral HPLC analysis, NMR, and elemental analysis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, cool place. This compound is moisture-sensitive (hygroscopic) and easily oxidized; prolonged exposure to air or ambient conditions should be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.