Description

[S(R)]-n-[(R)-[2-(Dicyclohexylphosphanyl)Phenyl](4-(tert-Butyl)Phenyl)Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated, chiral sulfinamide-phosphine hybrid ligand, representing a high-value building block in asymmetric synthesis. Its core value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for the synthesis of active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for palladium, rhodium, and iridium-catalyzed cross-coupling, hydrogenation, and allylic substitution reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the enantioselective construction of stereogenic centers in the development of novel drug candidates and APIs.
• Methodology Development: Serving as a key reagent in academic and industrial research for developing new catalytic asymmetric transformations.
• Fine Chemical Production: Used in the scalable synthesis of enantiomerically pure flavors, fragrances, and advanced materials.
• Agrochemical Research: Facilitating the creation of chiral active ingredients for herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.

Basic Information

Product Name	[S(R)]-n-[(R)-[2-(Dicyclohexylphosphanyl)Phenyl](4-(tert-Butyl)Phenyl)Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-61-0
Molecular Formula	C34H52NOPS
Molecular Weight	553.81 g/mol
Synonyms	(S)-N-[(R)-(2-(Dicyclohexylphosphino)phenyl)(4-(tert-butyl)phenyl)methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; Josiphos-type Sulfinamide Ligand; Hybrid P,N-Ligand; Asymmetric Catalysis Ligand; tert-Butylsulfinamide-Dicyclohexylphosphine Derivative; (S(R),R(C))-N-((R)-(2-(Dicyclohexylphosphanyl)phenyl)(4-(tert-butyl)phenyl)methyl)-2-methylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by NMR (1H, 13C, 31P), HPLC for chiral purity, and elemental analysis. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and full analytical data to support your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or ambient conditions should be avoided to maintain purity and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.