Description

[S(R)]-n-[(S)-(3,5-Di-tert-Butyl-4-Methoxyphenyl)[2-(Di-tert-Butylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a high-value specialty chemical for advanced synthetic chemistry. Its primary value lies in enabling highly selective and efficient asymmetric transformations, particularly in the synthesis of complex pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in catalytic reactions.

Application

• Asymmetric Catalysis: As a privileged ligand for transition metal catalysts (e.g., Rh, Ir, Pd) in enantioselective hydrogenation, hydroformylation, and cross-coupling reactions.
• Pharmaceutical Intermediate Synthesis: Critical for the stereocontrolled construction of chiral centers in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Development: A valuable tool for academic and industrial research into new catalytic asymmetric synthetic protocols.
• Fine Chemical Production: Enables the commercial-scale manufacture of high-value chiral flavors, fragrances, and electronic chemicals.
• Ligand Library Screening: Serves as a key component in high-throughput screening for discovering new catalytic systems with unique selectivity profiles.

Basic Information

Product Name	[S(R)]-n-[(S)-(3,5-Di-tert-Butyl-4-Methoxyphenyl)[2-(Di-tert-Butylphosphino)Phenyl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-54-1
Molecular Formula	C40H60NO2PS
Molecular Weight	649.93 g/mol
Synonyms	(SR)-N-[(S)-(3,5-Di-tert-butyl-4-methoxyphenyl)(2-(di-tert-butylphosphino)phenyl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-(3,5-Di-t-butyl-4-methoxyphenyl)(2-(di-t-butylphosphino)phenyl)methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; t-Bu-Sulfinamide Phosphine Ligand; DTBM-SEGPHOS Sulfinamide Derivative; Asymmetric Sulfinamide Ligand; Contact for additional synonyms.
EINECS	Not yet assigned. Contact for details.

Quality Control

Our production of this high-purity chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and performance reliability. Each lot is characterized by comprehensive analytical techniques including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific parameters is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (argon or nitrogen) to prevent oxidation and moisture uptake. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.