Description

[S(R)]-n-[(R)-[2-(Dicyclohexylphosphino)Phenyl]-2-Naphthalenylmethyl]-2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in modern asymmetric synthesis. Its primary value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-enantiomer pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control.

Application

• Asymmetric Catalysis: Serves as a privileged ligand for palladium, rhodium, and iridium catalysts in cross-coupling, hydrogenation, and hydroformylation reactions.
• Pharmaceutical Intermediate Synthesis: Critical for the enantioselective construction of chiral centers in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development in organic and organometallic chemistry laboratories.
• Fine Chemical Production: Enables the commercial-scale synthesis of high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	[S(R)]-n-[(R)-[2-(Dicyclohexylphosphino)Phenyl]-2-Naphthalenylmethyl]-2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-53-0
Molecular Formula	C35H44NOPS
Molecular Weight	557.77 g/mol
Synonyms	(S)-tert-Butanesulfinamide, (R)-[2-(Dicyclohexylphosphino)phenyl]-2-naphthalenylmethyl derivative; (R)-[2-(Dicyclohexylphosphino)phenyl]-2-naphthylmethyl tert-Butanesulfinamide; Chiral Sulfinamide-Phosphine Ligand; Dicyclohexylphosphino-based Sulfinamide; Asymmetric Synthesis Ligand CAS 2565792-53-0
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced under strict quality-controlled conditions to ensure exceptional purity and enantiomeric excess, which are critical for catalytic performance. We provide comprehensive Certificates of Analysis (COA) detailing purity (by HPLC/NMR), chiral purity, and identity confirmation. Our quality system is designed to support cGMP and ISO standards for traceability, making our products suitable for demanding pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.