Description

Pyridine, 2-[(2S,3S)-3-(1,1-Dimethylethyl)-2,3-dihydro-4-methoxy-1,3-benzoxaphosphol-2-yl]- is a specialized chiral organophosphorus compound featuring a fused benzoxaphosphole and pyridine heterocyclic system. This compound is of significant value as a key chiral intermediate or ligand in advanced synthetic chemistry, particularly for asymmetric catalysis and pharmaceutical development. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex, optically active molecules. The compound is identified by CAS No. 2565792-52-9.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring specific stereochemistry.
• Asymmetric Catalysis: Functions as a chiral ligand or precursor for ligands in transition metal-catalyzed reactions, such as asymmetric hydrogenation or cross-coupling.
• Agrochemical Research: Used in the development of new, more selective pesticides and herbicides where chirality impacts biological activity.
• Material Science: Potential application in the synthesis of chiral organic frameworks or functional materials with specific optical properties.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic synthesis and scale-up process optimization in fine chemical production.

Basic Information

Product Name	Pyridine, 2-[(2S,3S)-3-(1,1-Dimethylethyl)-2,3-dihydro-4-methoxy-1,3-benzoxaphosphol-2-yl]-
CAS No.	2565792-52-9
Molecular Formula	C19H24NO2P
Molecular Weight	329.38 g/mol
Synonyms	(2S,3S)-2-(Pyridin-2-yl)-3-(tert-butyl)-2,3-dihydro-4-methoxy-1,3-benzoxaphosphole; 2-[(2S,3S)-3-(tert-Butyl)-2,3-dihydro-4-methoxy-1,3-benzoxaphosphol-2-yl]pyridine; Chiral Benzoxaphosphole-Pyridine Ligand; (2S,3S)-3-tert-Butyl-4-methoxy-2-(pyridin-2-yl)-2,3-dihydro-1,3-benzoxaphosphole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) detailing specifications such as enantiomeric excess (ee), chemical assay, and impurity profiles are available upon request. We adhere to a cGMP-compliant quality management system for production relevant to pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.