Description

[S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a significant advancement in asymmetric catalysis. Its value lies in its ability to induce high enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of complex, single-enantiomer molecules. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance catalysts for producing active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for creating chiral centers in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed asymmetric cross-couplings, such as Suzuki-Miyaura and Buchwald-Hartwig amination, to construct biaryl and C-N bonds with high optical purity.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of chiral drug candidates, particularly for central nervous system (CNS) agents, oncology therapeutics, and antiviral compounds.
• Agrochemical Product Development: Facilitates the production of enantiomerically pure herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for optimizing catalytic processes in industrial settings.
• Fine Chemical Manufacturing: Enables the commercial production of specialty flavors, fragrances, and advanced materials requiring specific chirality.

Basic Information

Product Name	[S(R)]-n-[(R)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Dicyclohexylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-49-4
Molecular Formula	C39H60NO2PS
Molecular Weight	637.93 g/mol
Synonyms	(S,R)-JosiPhos Sulfinamide Ligand; (S,R)-JosiPhos-Sulfinamide; (S,R)-Sulfinamide JosiPhos; (S,R)-SKP Ligand; (S,R)-t-Bu-JosiPhos Sulfinamide; (S,R)-DTBM-SEGPHOS Sulfinamide Analog; N,2-Dimethyl-2-propanesulfinamide, N-[[(R)-[3,5-bis(1,1-dimethylethyl)-4-methoxyphenyl][2-(dicyclohexylphosphino)phenyl]methyl]-, (S)-
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for sensitive catalytic applications. Standard quality verification includes HPLC purity analysis, chiral purity determination, and NMR spectroscopic confirmation of structure and enantiomeric excess (ee). A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a dry, cool place. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided to maintain catalytic activity and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.