Description

[S(R)]-n-[(R)-(3,5-Di-tert-Butyl-4-Methoxyphenyl)[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl]-2-Methyl-2-Propanesulfinamide is a highly specialized chiral sulfinamide-phosphine hybrid ligand, designed for advanced asymmetric synthesis. Its value lies in enabling precise stereocontrol in critical catalytic transformations, particularly in the synthesis of complex pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-performance, enantioselective catalysts.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric hydrogenation reactions.
• For enantioselective synthesis of active pharmaceutical ingredients (APIs) and key chiral intermediates.
• In the development of novel catalytic systems for C-C and C-X bond-forming reactions.
• As a critical reagent in process chemistry for scaling up the production of optically pure compounds.
• For research into new asymmetric methodologies in academic and industrial laboratories.
• Potential use in the synthesis of agrochemicals and flavors & fragrances requiring specific stereochemistry.

Basic Information

Product Name	[S(R)]-n-[(R)-(3,5-Di-tert-Butyl-4-Methoxyphenyl)[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-47-2
Molecular Formula	C39H48NO4PS
Molecular Weight	657.83 g/mol
Synonyms	(SR,R)-N-[(R)-(3,5-Di-tert-butyl-4-methoxyphenyl){2-(diphenylphosphanyl)-4,5-dimethoxyphenyl}methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; (SR,R)-DTBM-SEGPHOS Sulfinamide; Asymmetric Hydrogenation Ligand; SEGPHOS-Derived Sulfinamide Ligand; (SR,R)-N-[(R)-(3,5-Di-t-butyl-4-methoxyphenyl){2-(diphenylphosphino)-4,5-dimethoxyphenyl}methyl]-2-methyl-2-propanesulfinamide; (SR,R)-Ligand for Asymmetric Catalysis
EINECS	Contact for details

Quality Control

Our production of this advanced chiral ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for reproducible catalytic performance. Each lot is characterized by comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and chiral integrity.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). This compound is easily oxidized and moisture-sensitive; prolonged exposure to air or humidity should be avoided. Keep the container sealed and desiccated when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.