Description

[S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl]-2-Naphthalenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric synthesis. Its value lies in enabling highly enantioselective transition metal-catalyzed reactions, which are essential for producing single-enantiomer pharmaceuticals and fine chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex chiral molecules with high precision. The CAS number for this compound is 2565792-44-9.

Application

This specialized chiral ligand finds its primary utility in advanced catalytic processes where high stereocontrol is paramount.

• Asymmetric Hydrogenation: A key catalyst component for the enantioselective reduction of prochiral olefins, ketones, and imines, a fundamental step in chiral amine and alcohol synthesis.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, oncology, and infectious diseases.
• Cross-Coupling Reactions: Can be employed in asymmetric versions of Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to create chiral biaryl structures.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators for enhanced efficacy and environmental safety.
• Academic & Industrial R&D: Serves as a valuable tool for methodology development in organic chemistry and for exploring new catalytic transformations.
• Fine Chemical Production: Applicable in the manufacture of chiral flavors, fragrances, and specialty materials requiring specific handedness.

Basic Information

Item	Details
Product Name	[S(R)]-n-[(S)-[2-(Dicyclohexylphosphino)Phenyl]-2-Naphthalenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-44-9
Molecular Formula	C36H46NOPS
Molecular Weight	571.79 g/mol
Synonyms	(SR)-N-[(S)-[2-(Dicyclohexylphosphino)phenyl](naphthalen-2-yl)methyl]-N,2-dimethylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; (S)-[2-(Dicyclohexylphosphino)phenyl]-2-naphthalenylmethyl tert-Butanesulfinamide derivative; Asymmetric Hydrogenation Ligand; (SR,S)-DPP-Nap-Sulfinamide; Hybrid P,N/S=O Ligand; Contact for additional synonyms.
EINECS	Not yet assigned / Contact for details

Quality Control

Every batch of our chiral ligands is produced and controlled under strict quality management systems to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation. Our standard specifications are designed to meet the rigorous demands of pharmaceutical R&D and process chemistry. For custom purity grades or specific analytical requirements, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light may degrade performance. Keep the container in a cool, dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.