Description

[S(R)]-n-[(1S)-1-[2-(Dicyclohexylphosphanyl)Phenyl]-2,2-Dimethylpropyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a significant advancement in asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, crucial for synthesizing complex pharmaceutical intermediates and fine chemicals with precise stereochemistry. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-performance, tunable ligands for metal-catalyzed cross-coupling and hydrogenation reactions.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, including Suzuki-Miyaura, Heck, and Negishi cross-couplings.
• For the enantioselective synthesis of active pharmaceutical ingredients (APIs) and key chiral intermediates.
• In catalyst development and screening for novel asymmetric transformations in academic and industrial R&D.
• As a precursor or modifier for immobilized catalysts used in flow chemistry applications.
• For the production of agrochemicals and specialty chemicals requiring high enantiomeric purity.
• In methodological studies to explore new C-C and C-X bond-forming reactions under mild conditions.

Basic Information

Product Name	[S(R)]-n-[(1S)-1-[2-(Dicyclohexylphosphanyl)Phenyl]-2,2-Dimethylpropyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-30-3
Molecular Formula	C29H42NOPS
Molecular Weight	483.70 g/mol
Synonyms	(S)-N-((S)-1-(2-(Dicyclohexylphosphino)phenyl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1S)-1-[2-(dicyclohexylphosphino)phenyl]-2,2-dimethylpropyl]-; Chiral Sulfinamide-Phosphine Ligand; Josiphos-type sulfinamide ligand; Asymmetric sulfinamide phosphine ligand; P,N-Ligand; Dicyclohexyl(2-((S)-((S)-tert-butylsulfinyl)amino)-3,3-dimethyl-1-phenylbutyl)phosphine
EINECS	Contact for details

Quality Control

Every batch of this advanced chiral ligand is produced under strict quality control protocols to ensure consistency and performance in sensitive catalytic applications. Our products undergo rigorous analytical testing, including chiral HPLC, 31P/1H/13C NMR, and elemental analysis, to verify high chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The compound is easily oxidized and moisture-sensitive; therefore, the container should be flushed with inert gas after each opening and stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.