Description

[S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl]Ethyl]-2-Methyl-2-Propanesulfinamide CAS NO 2565792-27-8 is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a high-value building block in modern asymmetric synthesis. Its core value lies in enabling precise stereochemical control in transition metal-catalyzed reactions, which is critical for producing enantiomerically pure pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require highly selective catalysts for complex bond-forming transformations.

Application

• Asymmetric Hydrogenation: Serves as a key chiral ligand for rhodium or ruthenium catalysts in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in the synthesis of active pharmaceutical ingredients (APIs) with high enantiomeric excess (ee).
• Cross-Coupling Catalysis: Used in palladium-catalyzed asymmetric cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig amination, to form C-C and C-N bonds stereoselectively.
• Agrochemical Research: Employed in the development of chiral herbicides, fungicides, and pesticides where biological activity is stereospecific.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up novel catalytic processes in fine chemical production.
• Ligand Library Development: Used as a component in high-throughput screening for discovering new catalytic systems in asymmetric synthesis.

Basic Information

Product Name	[S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl]Ethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2565792-27-8
Molecular Formula	C41H41NO3P2S
Molecular Weight	689.79 g/mol
Synonyms	(SR)-N-[(1S)-2-(Diphenylphosphino)-1-[2-(diphenylphosphino)-4,5-dimethoxyphenyl]ethyl]-2-methylpropane-2-sulfinamide; (SR,S)-Sulfinamide-Phosphine Ligand; Chiral Sulfinyl Diphosphine Ligand; Asymmetric Hydrogenation Ligand; (SR)-N-[(1S)-1-[2-(Diphenylphosphino)-4,5-dimethoxyphenyl]-2-(diphenylphosphino)ethyl]-2-methylpropane-2-sulfinamide; CAS 2565792-27-8
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. Standard quality parameters include HPLC purity, chiral purity (enantiomeric excess), and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity, store under an inert atmosphere (argon or nitrogen) at a controlled room temperature (15-25°C). This compound is easily oxidized; prolonged exposure to air should be avoided. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.