Description

[S(R)]-n-[(R)-[2-(Dicyclohexylphosphino)Phenyl]Phenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a critical component in asymmetric synthesis. This compound matters because it enables highly enantioselective transition metal-catalyzed reactions, such as cross-couplings and hydrogenations, which are essential for producing single-enantiomer pharmaceuticals and fine chemicals. Pharmaceutical R&D laboratories, advanced academic research groups, and manufacturers of high-value chiral intermediates are the primary users who need this ligand to achieve superior stereochemical control in their synthetic processes.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for palladium, rhodium, and iridium catalysts in enantioselective C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: For the production of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in complex, late-stage functionalization steps.
• Academic & Industrial Research: A valuable tool for developing novel catalytic methodologies and exploring new chemical space in medicinal chemistry programs.
• Fine Chemical Manufacturing: Used in the scalable synthesis of specialty chemicals, agrochemicals, and flavors & fragrances requiring high enantiomeric excess.
• Material Science: Potential application in the synthesis of chiral polymers or frameworks with specific optical properties.

Basic Information

Product Name	[S(R)]-n-[(R)-[2-(Dicyclohexylphosphino)Phenyl]Phenylmethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2565792-19-8
Molecular Formula	C30H44NOPS
Molecular Weight	497.72 g/mol
Synonyms	(S)-N-[(R)-(2-(Dicyclohexylphosphino)phenyl)(phenyl)methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; Josiphos-type Sulfinamide Ligand; Hybrid P,N-Ligand; (S,R)-sulfinamide-dicyclohexylphosphine ligand; (S)-N-((R)-(2-(Dicyclohexylphosphino)phenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide; Asymmetric Catalysis Ligand 2565792-19-8
EINECS	Contact for details

Quality Control

Every batch of our chiral ligand is produced and tested under strict quality management to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity confirmation. Our standard analytical suite includes HPLC, 1H/31P/13C NMR, and specific rotation measurements to guarantee the material meets the exacting standards required for asymmetric synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. The material is light-sensitive and easily oxidized; handling should be performed in a glovebox or using standard Schlenk techniques to maintain purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity	≥ 99.0% ee
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.