Description

[S(R)]-n-[(S)-(4-Methoxyphenyl)[2-(Di-tert-Butylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceutical intermediates and fine chemicals. This advanced ligand is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel synthetic routes.

Application

• Asymmetric Hydrogenation: As a chiral ligand for transition metal catalysts (e.g., Rh, Ru, Ir) in the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs), particularly for complex drug molecules.
• Cross-Coupling Reactions: Facilitating enantioselective C-C and C-X bond-forming reactions in fine chemical synthesis.
• Agrochemical Research: Development of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis research.
• Process Chemistry Optimization: Scaling up enantioselective catalytic processes from laboratory to pilot plant and production.

Basic Information

Product Name	[S(R)]-n-[(S)-(4-Methoxyphenyl)[2-(Di-tert-Butylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2561513-54-8
Molecular Formula	C27H40NO2PS
Molecular Weight	473.66 g/mol
Synonyms	(SR)-N-[(S)-(4-Methoxyphenyl)(2-(Di-tert-butylphosphino)phenyl)methyl]-N,2-dimethylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; tBu-SMS-Phos; DTBP-Sulfinamide Ligand; Asymmetric Sulfinamide Phosphine Ligand; (S)-[S(R)]-N-[1-(4-Methoxyphenyl)-2-(di-tert-butylphosphino)benzyl]-N,2-dimethylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and specific rotation is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is light-sensitive and easily oxidized; prolonged exposure to air or light may degrade its catalytic efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.