Description

1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, 4,10-Bis[2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]- is a highly functionalized macrocyclic chelator, a derivative of the foundational 1,4,7,10-tetraazacyclododecane (cyclen) scaffold. Its core value lies in its exceptional ability to form stable, high-affinity complexes with a wide range of metal ions, particularly lanthanides and transition metals, which is critical for advanced diagnostic and therapeutic applications. This compound is essential for researchers and manufacturers in the fields of medical imaging, targeted drug delivery, and advanced material science. Its multi-dentate structure, featuring both carboxylic acid and polyhydroxyl pendant arms, provides versatile coordination chemistry for creating next-generation contrast agents and radiopharmaceuticals.

Application

• Magnetic Resonance Imaging (MRI) Contrast Agents: As a bifunctional chelator for gadolinium (Gd³⁺) and other paramagnetic ions to enhance image contrast.
• Radiopharmaceuticals & Nuclear Medicine: Chelation platform for radionuclides (e.g., ⁶⁸Ga, ¹⁷⁷Lu, ⁹⁰Y) used in Positron Emission Tomography (PET) imaging and targeted radionuclide therapy.
• Fluorescent Probes & Sensors: Complexation with lanthanide ions (e.g., Eu³⁺, Tb³⁺) to create highly sensitive time-resolved fluorescence probes for bioassays and cellular imaging.
• Catalysis: Serving as a ligand to create well-defined metal complexes for homogeneous catalysis in organic synthesis.
• Metal Ion Separation & Extraction: Utilized in analytical chemistry and hydrometallurgy for the selective separation and recovery of specific metal ions from complex mixtures.
• Advanced Material Synthesis: Building block for constructing metal-organic frameworks (MOFs) or functional polymers with specific magnetic or optical properties.

Basic Information

Item	Details
Product Name	1,4,7,10-Tetraazacyclododecane-1,7-Diacetic Acid, 4,10-Bis[2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]-
CAS No.	2514736-58-2
Molecular Formula	C₂₂H₄₄N₄O₁₂
Molecular Weight	556.60 g/mol
Synonyms	DO3A-tris(hydroxymethyl)methylamide derivative; H₅DO3A-(CH₂OH)₃; 1,7-Bis(carboxymethyl)-4,10-bis[(2,3-dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane; Tris-hydroxymethyl-substituted DO3A; AAZTA-like chelator; Polyhydroxylated cyclen derivative; Bifunctional DOTA analogue
EINECS	Contact for details

Quality Control

Our production of this advanced chelator adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, which is critical for sensitive biomedical applications. Each lot undergoes comprehensive analysis including HPLC for purity assessment, NMR for structural confirmation, and elemental analysis (CHN). We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all relevant specifications. Our quality system is designed to support GMP-grade manufacturing for preclinical and clinical development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.