Description

Phosphine, Dicyclohexyl[3-(1,1-Dimethylethoxy)-6-Methoxy-2',6'-Bis(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]- is a specialized organophosphorus compound, a sterically hindered phosphine ligand of significant interest in advanced catalytic chemistry. Its molecular architecture is engineered to provide exceptional electron-donating properties and steric bulk, which are critical for modulating the activity and selectivity of transition metal catalysts. This high-value chemical is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel synthetic methodologies.

Application

• Homogeneous Catalysis: As a privileged ligand in cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) for C-C and C-N bond formation.
• Pharmaceutical Intermediate Synthesis: Enabling the construction of complex, chiral molecules in API (Active Pharmaceutical Ingredient) development.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators requiring precise stereochemical control.
• Material Science: Potential application in the synthesis of specialized polymers and OLED (Organic Light-Emitting Diode) materials.
• Asymmetric Synthesis: Serving as a chiral ligand precursor for the development of enantioselective hydrogenation and hydroformylation catalysts.

Basic Information

Product Name	Phosphine, Dicyclohexyl[3-(1,1-Dimethylethoxy)-6-Methoxy-2',6'-Bis(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]-
CAS No.	2489243-29-8
Molecular Formula	C36H55O2P
Molecular Weight	550.80 g/mol
Synonyms	Dicyclohexyl(3-tert-butoxy-6-methoxy-2',6'-diisopropyl-[1,1'-biphenyl]-2-yl)phosphine; cBRIDP; cBRIDP Ligand; BrettPhos-type ligand analog; 2-(Dicyclohexylphosphino)-3',5'-diisopropyl-6-methoxy-2'-(tert-butoxy)-1,1'-biphenyl; Sterically hindered biaryl phosphine ligand.
EINECS	Contact for details

Quality Control

Our production of this high-purity ligand adheres to stringent quality protocols. Every batch is characterized using advanced analytical techniques including NMR (¹H, ³¹P, ¹³C), HPLC, and GC to ensure structural integrity and purity. Certificates of Analysis (COA) detailing lot-specific data are provided with each shipment. We support cGMP compliance for applications in regulated industries, and specifications can be aligned with client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹H NMR	Conforms
³¹P NMR	Conforms
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.