Description

Benzene, 1,4-Difluoro-2-[1-(4-Methoxyphenyl)Ethyl]- is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorobenzene core substituted with a chiral 1-(4-methoxyphenyl)ethyl group. This compound is critical for enabling precise molecular modifications in drug discovery, particularly for enhancing metabolic stability and binding affinity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule therapeutics, especially kinase inhibitors and CNS-active compounds.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the difluoro and methoxy motifs contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating specialized aromatic compounds used in electronic display technologies.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions and as a ligand precursor in asymmetric catalysis due to its steric and electronic properties.
• Fluorine Chemistry Research: A valuable substrate for studying structure-activity relationships (SAR) in fluorinated aromatic systems.

Basic Information

Item	Detail
Product Name	Benzene, 1,4-Difluoro-2-[1-(4-Methoxyphenyl)Ethyl]-
CAS No.	2484889-24-7
Molecular Formula	C15H14F2O
Molecular Weight	248.27 g/mol
Synonyms	1,4-Difluoro-2-[1-(4-methoxyphenyl)ethyl]benzene; 2-(1-(4-Methoxyphenyl)ethyl)-1,4-difluorobenzene; 1,4-Difluoro-2-(1-(4-methoxyphenyl)ethyl)benzene; α-Methyl-4-methoxybenzene-1,4-difluorobenzene; (1-(4-Methoxyphenyl)ethyl)-1,4-difluorobenzene; 2484889-24-7; 2-(1-(4-Methoxyphenyl)ethyl)-1,4-Difluorobenzene
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1,4-Difluoro-2-[1-(4-Methoxyphenyl)Ethyl]- is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, GC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.