Description

2-Fluoro-5-Iodothioanisole is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents on a thioanisole core, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine and iodine atoms can modulate bioactivity and metabolic stability.
• Material Science: Serves as a building block for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its halogenated aromatic system.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Useful as a probe or tagging reagent in bioconjugation chemistry and for studying biological pathways.
• Custom Synthesis: A valuable starting material for contract research organizations (CROs) and fine chemical manufacturers engaged in custom synthesis projects.

Basic Information

Item	Details
Product Name	2-Fluoro-5-Iodothioanisole
CAS No.	2484889-20-3
Molecular Formula	C7H6FIS
Molecular Weight	268.09 g/mol
Synonyms	1-Fluoro-4-Iodo-2-(Methylthio)Benzene; 2-Fluoro-5-Iodophenyl Methyl Sulfide; 4-Fluoro-3-Iodothioanisole; Methyl(2-Fluoro-5-Iodophenyl) Sulfane; 1-(Methylsulfanyl)-2-Fluoro-4-Iodobenzene; 2-Fluoro-5-Iodo Thioanisole
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-Iodothioanisole is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as HPLC, GC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.