Description

Apatinib-D8 Hydrochloride is a deuterated isotopologue of the potent and selective VEGFR-2 inhibitor Apatinib, used as a critical internal standard in quantitative bioanalytical studies. This high-purity reference material is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic data in drug development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in oncology research and bioanalytical method validation.

Application

• Bioanalytical Internal Standard: Serves as a stable isotope-labeled internal standard for the precise quantification of Apatinib in biological matrices (e.g., plasma, serum, tissue) using LC-MS/MS.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Method Development & Validation: Critical for developing, optimizing, and validating robust, GLP-compliant bioanalytical assays.
• Drug-Drug Interaction Studies: Used in studies investigating the effect of co-administered drugs on Apatinib metabolism and clearance.
• Quality Control in Manufacturing: Can be employed as a reference standard for quality control of the non-deuterated active pharmaceutical ingredient (API).

Basic Information

Product Name	Apatinib-D8 Hydrochloride
CAS No.	2468771-44-8
Molecular Formula	C24H17D8ClN4O3•HCl
Molecular Weight	493.42 g/mol
Synonyms	YN968D1-D8 Hydrochloride; Rivoceranib-D8 Hydrochloride; (E)-N-(4-(1-Cyanocyclopentyl)phenyl)-2-((4-pyridinylmethyl)amino)-3-pyridinecarboxamide-D8 Hydrochloride; Apatinib (phenyl-D8) Hydrochloride; Apatinib-d8 HCl; Apatinib (phenyl-d8) hydrochloride; Apatinib-D8 HCl Salt
EINECS	Contact for details

Quality Control

Our Apatinib-D8 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Incorporation)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.