Description

1H-Indene-1-Pentanol, Octahydro-4-Hydroxy-ε,7A-Dimethyl-α,α-Bis(Trifluoromethyl)-, (εr,1R,3Ar,4S,7Ar)- is a high-value, complex chiral intermediate featuring a unique indene-derived scaffold with multiple stereocenters and trifluoromethyl groups. This compound is specifically engineered for advanced synthetic applications where precise molecular architecture and the introduction of fluorine atoms are critical for modulating the physical and biological properties of target molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by specialty chemical manufacturers exploring advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated compounds for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl groups can improve lipophilicity and biological activity.
• Advanced Material Synthesis: Acts as a precursor for specialty polymers, liquid crystals, or organic electronic materials that benefit from its rigid, functionalized structure.
• Catalyst & Ligand Development: Employed in the design of novel chiral catalysts or ligands for asymmetric synthesis, leveraging its complex stereochemistry.
• Chemical Biology Probes: Utilized in academic and industrial research to create molecular probes for studying enzyme mechanisms or biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization studies to enable the efficient commercial production of complex molecules.

Basic Information

Product Name	1H-Indene-1-Pentanol, Octahydro-4-Hydroxy-ε,7A-Dimethyl-α,α-Bis(Trifluoromethyl)-, (εr,1R,3Ar,4S,7Ar)-
CAS No.	2454249-03-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(1R,3aR,4S,7aR)-4-Hydroxy-α,α-bis(trifluoromethyl)-ε,7a-dimethyl-octahydro-1H-indene-1-pentanol; Octahydro-4-hydroxy-ε,7a-dimethyl-α,α-bis(trifluoromethyl)-1H-indene-1-pentanol; (εr,1R,3Ar,4S,7Ar)-1H-Indene-1-pentanol, octahydro-4-hydroxy-ε,7a-dimethyl-α,α-bis(trifluoromethyl)-; CAS 2454249-03-5.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture uptake. Recommended long-term storage temperature is 2-8°C. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.