Description

[S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Diphenylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, representing a high-value building block in advanced asymmetric synthesis. Its core value lies in enabling precise stereochemical control in catalytic transformations, which is critical for producing enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity, well-defined chiral auxiliaries and ligands for cutting-edge catalytic applications.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, including hydrogenation, cross-coupling, and C-H activation.
• Critical intermediate in the research and development of novel active pharmaceutical ingredients (APIs), particularly for creating single-enantiomer drugs.
• Use in asymmetric synthesis for the preparation of complex natural products and agrochemicals with defined stereocenters.
• As a chiral resolving agent or auxiliary in the separation and purification of enantiomeric mixtures.
• Fundamental research tool in organometallic chemistry and catalysis for studying structure-activity relationships of phosphine-sulfinamide ligands.
• Potential application in the synthesis of advanced materials with chiral properties.

Basic Information

Item	Details
Product Name	[S(R)]-n-[(S)-[3,5-Bis(1,1-Dimethylethyl)-4-Methoxyphenyl][2-(Diphenylphosphino)Phenyl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2454167-25-8
Molecular Formula	C41H52NO2PS
Molecular Weight	653.89 g/mol
Synonyms	(S,R)-DTBM-SEGPHOS Sulfinamide; N-[(S)-[3,5-Di-tert-butyl-4-methoxyphenyl][2-(diphenylphosphino)phenyl]methyl]-N,2-dimethylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; SEGPHOS-based Sulfinamide; Asymmetric Synthesis Ligand; tert-Butanesulfinamide Phosphine Derivative; (S)-N-((S)-[3,5-Bis(tert-butyl)-4-methoxyphenyl](2-(diphenylphosphanyl)phenyl)methyl)-2-methylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our production of this high-value chiral chemical adheres to stringent quality protocols. Every batch is characterized and purified to ensure high chiral purity and chemical integrity, with typical purity levels exceeding 97% (HPLC). Identity is confirmed via NMR, IR, and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing assay, enantiomeric excess (ee), and impurity profiles. Our quality management system supports cGMP and ISO standards for traceability and consistency, making this product suitable for demanding research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.