Description

S(R)]-n-((1S)-1-(2-(Diphenylphosphino)Phenyl)-2,2-Dimethylpropyl)-N,2-Dimethyl-2-Propanesulfinamide CAS NO 2454167-14-5 is a high-purity, chiral sulfinamide-phosphine hybrid ligand, a critical class of organocatalysts and auxiliaries in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in key bond-forming reactions, enabling the production of single-isomer pharmaceutical intermediates and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance chiral building blocks.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metal-catalyzed reactions, including cross-couplings, hydrogenations, and hydrosilylations.
• Pharmaceutical Intermediate Synthesis: For the enantioselective construction of complex molecules in active pharmaceutical ingredient (API) development.
• Chiral Auxiliary: In diastereoselective synthesis to control stereochemistry at specific carbon centers.
• Agrochemical Research: In the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Methodology Development: For academic and industrial research into new catalytic asymmetric transformations.
• Fine Chemical Production: For the manufacture of specialty chemicals where optical purity is a critical quality attribute.

Basic Information

Product Name	S(R)]-n-((1S)-1-(2-(Diphenylphosphino)Phenyl)-2,2-Dimethylpropyl)-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2454167-14-5
Molecular Formula	C29H36NOPS
Molecular Weight	477.64 g/mol
Synonyms	(S)-N-((S)-1-(2-(Diphenylphosphino)phenyl)-2,2-dimethylpropyl)-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; (S,S)-Sulfinamide Phosphine Hybrid Ligand; tert-Butanesulfinamide-Diphenylphosphine Derivative; Asymmetric Synthesis Ligand CAS 2454167-14-5; P,S-Bidentate Ligand; Chiral Auxiliary Ligand
EINECS	Contact for details

Quality Control

Every batch of this advanced chiral ligand is produced and tested under strict quality management to ensure consistency and performance in sensitive asymmetric syntheses. Standard quality parameters include chiral purity (enantiomeric excess) verified by chiral HPLC, identity confirmation by NMR and IR spectroscopy, and assay by quantitative NMR or titration. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.