Description

2-(3-Bromo-5-Chloro-2-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This advanced intermediate is essential for researchers and manufacturers in pharmaceutical development and agrochemical synthesis who require reliable, high-quality reagents for creating novel active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used to construct complex aromatic scaffolds found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & R&D Laboratories: A fundamental reagent for methodological development and complex molecule synthesis in academic and industrial research settings.

Basic Information

Item	Detail
Product Name	2-(3-Bromo-5-Chloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2446508-94-5
Molecular Formula	C12H14BBrClFO2
Molecular Weight	349.40 g/mol
Synonyms	3-Bromo-5-chloro-2-fluorophenylboronic acid pinacol ester; (3-Bromo-5-chloro-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-3-bromo-5-chlorophenylboronic acid pinacol ester; Pinacol (3-bromo-5-chloro-2-fluorophenyl)boronate; B-(3-Bromo-5-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2446508-94-5; Boronic acid, B-(3-bromo-5-chloro-2-fluorophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of our 2-(3-Bromo-5-Chloro-2-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard specifications are designed to meet the demanding requirements of pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.