Description

[S(R)]-n-[(S)-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl]-1-Naphthalenylmethyl]-2-Methyl-2-Propanesulfinamide CAS NO 2417456-74-5 is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, which is critical for producing single-isomer active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity chiral auxiliaries to streamline their synthetic routes.

Application

• As a chiral ligand in asymmetric hydrogenation, cross-coupling, and addition reactions.
• Critical component in the synthesis of enantiomerically pure pharmaceutical intermediates for drug discovery and development.
• Use in the preparation of advanced catalysts for academic and industrial research in organic synthesis.
• Employed in the asymmetric synthesis of agrochemicals and other bioactive molecules.
• As a key reagent for constructing complex molecular architectures in natural product synthesis.
• Application in methodological studies for developing new catalytic asymmetric transformations.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl]-1-Naphthalenylmethyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2417456-74-5
Molecular Formula	C35H36NO3PS
Molecular Weight	581.71 g/mol
Synonyms	(SR)-N-[(S)-[2-(Diphenylphosphino)-4,5-dimethoxyphenyl](1-naphthyl)methyl]-2-methylpropane-2-sulfinamide; (SR)-N-[(S)-[2-(Diphenylphosphino)-4,5-dimethoxyphenyl](naphthalen-1-yl)methyl]-2-methylpropane-2-sulfinamide; Sulfinamide-phosphine hybrid ligand; Chiral sulfinamide phosphine ligand; Asymmetric synthesis ligand; CAS 2417456-74-5
EINECS	Contact for details

Quality Control

Every batch of this high-value chiral ligand is produced and tested under strict quality control protocols to ensure batch-to-batch consistency and optimal performance in sensitive catalytic applications. Our standard pharmaceutical-grade material is characterized by comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.