Description

[S(R)]-n-[(S)-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl)](4-Methoxyphenyl)Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer active pharmaceutical ingredients (APIs) and advanced agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, reliable chiral auxiliaries and ligands.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation, cross-coupling, and allylic substitution.
• As a key chiral auxiliary in the stereoselective synthesis of complex organic molecules and natural products.
• In the research and development of novel pharmaceutical intermediates, particularly for central nervous system (CNS) and oncology targets.
• For the synthesis of enantiomerically pure agrochemicals, including herbicides and fungicides.
• In academic and industrial research focused on developing new catalytic methodologies.
• As a high-value intermediate in the production of other specialized chiral phosphine ligands.

Basic Information

Product Name	[S(R)]-n-[(S)-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl)](4-Methoxyphenyl)Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2417456-70-1
Molecular Formula	C32H36NO4PS
Molecular Weight	561.67 g/mol
Synonyms	(SR)-N-[(S)-[2-(Diphenylphosphino)-4,5-dimethoxyphenyl](4-methoxyphenyl)methyl]-2-methylpropane-2-sulfinamide; Chiral Sulfinamide-Phosphine Ligand; (S)-tert-Butanesulfinamide Derivative; Asymmetric Synthesis Ligand; CAS 2417456-70-1; (SR,S)-DPPOMe-Sulfinamide; tert-Butylsulfinyl Imine Precursor
EINECS	Contact for details

Quality Control

Our [S(R)]-n-[(S)-[2-(Diphenylphosphino)-4,5-Dimethoxyphenyl)](4-Methoxyphenyl)Methyl]-2-Methyl-2-Propanesulfinamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high chiral purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess. We adhere to cGMP guidelines where applicable, and our analytical methods, including HPLC, NMR, and chiral analysis, are validated to meet rigorous industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.