Description

Meplazumab is a humanized monoclonal antibody targeting CD147, a glycoprotein involved in various cellular signaling pathways. This compound is of significant interest for its potential therapeutic applications in treating infectious diseases, including malaria and viral infections. It is primarily utilized by pharmaceutical research organizations, biotechnology companies, and academic institutions engaged in the development of novel biologics and immunotherapies.

Application

• Pharmaceutical Research & Development: As a key investigational biologic for preclinical and clinical studies targeting CD147-mediated pathways.
• Therapeutic Antibody Development: Serves as a reference standard or active pharmaceutical ingredient (API) in the formulation of biologic drug candidates.
• Infectious Disease Research: Investigation of its mechanism of action against Plasmodium parasites for potential anti-malarial therapies.
• Immunology Studies: Used as a tool to study the role of CD147 in immune cell activation, inflammation, and viral entry processes.
• Biomarker & Diagnostic Tool Development: Potential use in assay development for detecting CD147 expression levels in research settings.
• Cell Culture & In Vitro Studies: Application in functional assays to understand cell signaling, proliferation, and infection mechanisms.

Basic Information

Product Name	Meplazumab
CAS No.	2413715-21-4
Molecular Formula	Contact for details
Molecular Weight	Approx. 145-150 kDa (Contact for details)
Synonyms	Anti-CD147 Monoclonal Antibody (Humanized); hIgG1-κ anti-CD147; Meplazumab (INN); Anti-Basigin Antibody; Anti-EMMPRIN Antibody; CD147 Inhibitor; Monoclonal Antibody 059-053
EINECS	Contact for details

Quality Control

Our Meplazumab is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Quality is assured through a comprehensive battery of analytical tests including SDS-PAGE, size-exclusion chromatography (SEC-HPLC), and endotoxin testing. A Certificate of Analysis (COA) detailing purity, potency, and biological activity is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant when applicable.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Purity (SEC-HPLC)	≥ 90% (Monomer)
Protein Concentration	≥ 1.0 mg/mL (after reconstitution)
Endotoxin Level	< 1.0 EU/mg
Biological Activity (Binding ELISA)	Contact for details
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.