Description

Pyridine, 2-[[[2-[[Bis(1,1-Dimethylethyl)Phosphino]Methyl]Phenyl]Methyl](1,1-Dimethylethyl)Phosphino]- is a sophisticated, sterically hindered bidentate phosphine ligand designed for advanced catalytic applications. Its value lies in its ability to impart high selectivity and activity in transition metal-catalyzed cross-coupling and hydrogenation reactions, which are critical for constructing complex molecular architectures. This high-purity specialty chemical is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance ligands for asymmetric synthesis and challenging bond-forming reactions.

Application

This specialized ligand finds its primary use in facilitating high-value chemical transformations:

• Asymmetric Catalysis: As a key component in chiral catalysts for enantioselective synthesis of active pharmaceutical ingredients (APIs) and agrochemical intermediates.
• Cross-Coupling Reactions: Enabling efficient Suzuki-Miyaura, Heck, and Buchwald-Hartwig amination reactions under mild conditions.
• Hydrogenation & Reduction: Serving as a ligand for precious metal catalysts in the selective hydrogenation of olefins, ketones, and imines.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and optimizing synthetic routes in process chemistry.
• Fine Chemical Synthesis: Production of complex, high-value molecules where precise stereochemical control is paramount.

Basic Information

Item	Details
Product Name	Pyridine, 2-[[[2-[[Bis(1,1-Dimethylethyl)Phosphino]Methyl]Phenyl]Methyl](1,1-Dimethylethyl)Phosphino]-
CAS No.	2410085-45-7
Molecular Formula	C27H43NP2
Molecular Weight	443.59 g/mol
Synonyms	2-((Di-tert-butylphosphino)methyl)-1-((2-((di-tert-butylphosphino)methyl)phenyl)methyl)pyridine; dtbpxpy; 2-((Di-tert-butylphosphino)methyl)-1-((2-((di-tert-butylphosphino)methyl)benzyl)pyridine; Pyridine-based bidentate phosphine ligand; P^N Ligand; (Pyridin-2-ylmethyl)phosphine ligand; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this high-value ligand adheres to stringent quality protocols to ensure batch-to-batch consistency and performance reliability. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and elemental analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We operate under a quality management system and can support development projects requiring compliance with cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. Due to its sensitivity, the material should be handled in a dry, oxygen-free environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.