Description

7-Keto Abiraterone Acetate is a key pharmaceutical intermediate and reference standard in the development and quality control of advanced oncology therapeutics. This compound is of significant importance for researchers and manufacturers focused on next-generation androgen biosynthesis inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and analytical service providers engaged in the production and validation of active pharmaceutical ingredients (APIs) for prostate cancer treatments.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the identification, assay, and impurity profiling of Abiraterone Acetate and related compounds in accordance with pharmacopeial methods (e.g., USP, EP).
• Process Chemistry & R&D: Serves as a critical intermediate or starting material in synthetic pathways for developing novel steroidal compounds and exploring structure-activity relationships (SAR).
• Impurity Control: Employed as a specified impurity marker in the quality control of Abiraterone Acetate API batches to ensure compliance with stringent regulatory purity specifications.
• Metabolite Studies: Utilized in preclinical and clinical research to study the metabolism, pharmacokinetics, and biological activity of Abiraterone and its derivatives.
• Analytical Method Development: Acts as a key component for developing and validating robust HPLC, UPLC, or LC-MS methods for potency and related substance analysis.

Basic Information

Product Name	7-Keto Abiraterone Acetate
CAS No.	2410075-48-6
Molecular Formula	C26H31NO3
Molecular Weight	405.53 g/mol
Synonyms	(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7,16-trione 3-acetate; 7-Oxoabiraterone acetate; 7-Oxo Abiraterone Acetate; 16,17-Didehydro-3β-(acetyloxy)-10,13-dimethyl-7-oxo-17-(3-pyridinyl)-2,3,4,7,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-ium
EINECS	Contact for details

Quality Control

Our 7-Keto Abiraterone Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting full compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.