Description

Pyridine, 5-(Diphenylphosphino)-2-(Trifluoromethyl)- is a specialized organophosphorus ligand featuring a pyridine backbone substituted with a diphenylphosphino group and a trifluoromethyl group. This compound matters as a highly tunable ligand for transition metal catalysis, offering unique electronic and steric properties to enhance reaction selectivity and efficiency. It is primarily needed by researchers and process chemists in the pharmaceutical and fine chemical industries for developing novel synthetic routes, particularly in cross-coupling reactions and asymmetric hydrogenations.

Application

• As a ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) for pharmaceutical intermediate synthesis.
• Utilized in asymmetric catalysis for the production of chiral active pharmaceutical ingredients (APIs).
• Employed in homogeneous catalysis research for developing new catalytic systems in academic and industrial R&D.
• Acts as a key precursor or modifier for creating tailored catalyst complexes with specific activity profiles.
• Used in material science research for the synthesis of functionalized molecules and polymers.
• Applied in process chemistry optimization to improve yield and selectivity in scale-up manufacturing.

Basic Information

Product Name	Pyridine, 5-(Diphenylphosphino)-2-(Trifluoromethyl)-
CAS No.	2408844-78-8
Molecular Formula	C24H17F3NP
Molecular Weight	407.37 g/mol
Synonyms	5-(Diphenylphosphino)-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-5-(diphenylphosphino)pyridine; (5-Pyridinyl)diphenylphosphine, 2-(trifluoromethyl)-; 5-(Diphenylphosphanyl)-2-(trifluoromethyl)pyridine; Ligand L1 (context-specific); P,N-Ligand; Trifluoromethyl-substituted phosphinopyridine
EINECS	Contact for details

Quality Control

Our Pyridine, 5-(Diphenylphosphino)-2-(Trifluoromethyl)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ³¹P), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The material is easily oxidized and light-sensitive.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.