Description

Mal-Peg4-Glu(Tfp Ester)-Nh-m-Peg24 CAS NO 2408741-87-5 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a tetrafluorophenyl (Tfp) ester group, separated by a branched PEG spacer. This compound is engineered for the site-specific conjugation of thiol-containing molecules (via the maleimide) and amine-containing molecules (via the activated Tfp ester), offering superior control and efficiency in bioconjugation workflows. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, antibody-drug conjugate (ADC) production, and advanced diagnostic assay formulation, where precise and stable linker chemistry is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the controlled, site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Protein/Peptide PEGylation: To modify therapeutic proteins or peptides, enhancing solubility, stability, and circulation half-life.
• Biomolecule Immobilization: For creating stable, oriented surfaces on biosensors, microarrays, and affinity chromatography resins.
• Fluorescent Probe & Diagnostic Reagent Synthesis: In the construction of labeled antibodies, proteins, or nanoparticles for imaging and detection.
• Nanoparticle Functionalization: To attach targeting ligands, drugs, or imaging agents to liposomes, polymersomes, or other nanocarriers.
• Crosslinking Agent: For creating defined protein-protein or protein-polymer conjugates in structural biology and materials science.

Basic Information

Item	Details
Product Name	Mal-Peg4-Glu(Tfp Ester)-Nh-m-Peg24
CAS No.	2408741-87-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Maleimide-PEG4-Glu-Tfp-PEG24-amine; m-PEG24-NH-Glu(Tfp ester)-PEG4-Maleimide; Heterobifunctional PEG Crosslinker, Maleimide and Tfp Ester; TFP-PEG24-NH-Glu-PEG4-MAL; 4-Arm PEG Crosslinker, Maleimide-Tfp Ester; N-(3-Maleimidopropionyl)-Glu(Tfp ester)-PEG24-amine; CAS 2408741-87-5
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Glu(Tfp Ester)-Nh-m-Peg24 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as purity, functional group activity, and moisture content.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (HPLC/MS)	Complies
Purity (HPLC)	≥ 95%
Functional Group Assay (Maleimide)	≥ 90%
Functional Group Assay (Tfp Ester)	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, moderately soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.