Description

2-Propanesulfinamide, n-[(1S)-1-[2',6'-Bis(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-, [S(R)]- is a sophisticated chiral ligand and organocatalyst, specifically designed for asymmetric synthesis. This compound matters because it enables high enantioselectivity and yield in critical carbon-carbon and carbon-heteroatom bond-forming reactions, which are essential for creating single-enantiomer pharmaceuticals and advanced materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and complex molecular architectures.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, such as hydrogenation and cross-coupling.
• As an organocatalyst for enantioselective additions to imines and carbonyl compounds.
• Key intermediate in the research and development of pharmaceutical active ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Use in the synthesis of agrochemicals requiring specific stereochemistry for enhanced activity and environmental profile.
• Building block for advanced materials and specialty chemicals with chiral properties.
• Tool compound in methodology development within academic and industrial organic chemistry laboratories.

Basic Information

Product Name	2-Propanesulfinamide, n-[(1S)-1-[2',6'-Bis(1-Methylethyl)[1,1'-Biphenyl]-2-Yl]-2-(Diphenylphosphino)Ethyl]-2-Methyl-, [S(R)]-
CAS No.	2394923-85-2
Molecular Formula	C43H48NOPS
Molecular Weight	657.88 g/mol
Synonyms	(SR)-N-[(1S)-1-[2',6'-Bis(1-methylethyl)[1,1'-biphenyl]-2-yl]-2-(diphenylphosphino)ethyl]-2-methylpropane-2-sulfinamide; (SR)-2-Methyl-N-[(1S)-1-[2',6'-di(propan-2-yl)[1,1'-biphenyl]-2-yl]-2-(diphenylphosphanyl)ethyl]propane-2-sulfinamide; Chiral Sulfinamide-Phosphine Hybrid Ligand; Biphenyl-based Josiphos-type sulfinamide ligand; Asymmetric synthesis ligand 2394923-85-2
EINECS	Contact for details

Quality Control

Our high-value chiral chemicals are produced under strict quality control protocols to ensure batch-to-batch consistency and optimal performance in sensitive asymmetric syntheses. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.