Description

Benzene, 2-Bromo-5-Iodo-1,3-Bis(Trifluoromethyl)- is a highly functionalized, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromo and iodo substituents alongside two trifluoromethyl groups, makes it a versatile precursor for constructing complex molecules via selective cross-coupling reactions. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scale-up of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, particularly those requiring fluorinated or halogenated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl groups often enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials with unique optical or electronic properties.
• Cross-Coupling Reactions: The differentiated bromo and iodo handles allow for sequential, site-selective metal-catalyzed couplings (e.g., Suzuki, Sonogashira, Negishi) to create highly complex, polyfunctionalized arenes.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated chelating ligands or organocatalysts for asymmetric synthesis.
• Fluorine Chemistry: An important substrate for studying the influence of multiple CF3 groups on aromatic system reactivity and for introducing fluorine motifs into target molecules.

Basic Information

Product Name	Benzene, 2-Bromo-5-Iodo-1,3-Bis(Trifluoromethyl)-
CAS No.	2383655-21-6
Molecular Formula	C8H2BrF6I
Molecular Weight	448.90 g/mol
Synonyms	1-Bromo-4-iodo-2,6-bis(trifluoromethyl)benzene; 2-Bromo-5-iodo-1,3-bis(trifluoromethyl)benzene; 2,6-Bis(trifluoromethyl)-1-bromo-4-iodobenzene; 1,3-Bis(trifluoromethyl)-2-bromo-5-iodobenzene; Bromo-iodo-bis(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Every batch of Benzene, 2-Bromo-5-Iodo-1,3-Bis(Trifluoromethyl)- is produced and analyzed under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR (1H, 19F, 13C), and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support custom purity requirements for specific R&D or scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.