Description

Pomalidomide-Peg3-Nh2 Hydrochloride is a high-purity, functionalized derivative of the immunomodulatory agent pomalidomide, designed for advanced pharmaceutical research and development. This compound is engineered as a key intermediate for the synthesis of antibody-drug conjugates (ADCs) and targeted therapeutics, offering a cleavable linker and a reactive amine group for precise bioconjugation. It is primarily utilized by research institutions and pharmaceutical companies focused on oncology drug discovery, targeted drug delivery systems, and the development of novel proteolysis-targeting chimeras (PROTACs).

Application

• Antibody-Drug Conjugate (ADC) Synthesis: Serves as a critical linker-payload component, connecting cytotoxic agents to monoclonal antibodies for targeted cancer therapy.
• PROTAC (Proteolysis-Targeting Chimera) Development: Acts as a versatile building block for constructing heterobifunctional molecules designed to degrade specific disease-causing proteins.
• Bioconjugation and Chemical Biology: Provides a reactive amine handle (NH2) for coupling with various targeting ligands, fluorophores, or other functional molecules in probe development.
• Pharmaceutical Intermediate: Used in the research-scale synthesis of novel pomalidomide analogs and next-generation immunomodulatory drugs (IMiDs).
• Targeted Drug Delivery Systems: Incorporated into nanoparticles, liposomes, or polymer-drug conjugates to enhance specificity and reduce off-target effects.

Basic Information

Product Name	Pomalidomide-Peg3-Nh2 Hydrochloride
CAS No.	2380273-75-4
Molecular Formula	C24H33ClN4O8
Molecular Weight	541.00 g/mol
Synonyms	Pomalidomide-PEG3-amine hydrochloride; 4-((2-(2-(2-Aminoethoxy)ethoxy)ethoxy)methyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride; Pomalidomide-PEG3-NH2.HCl; Pomalidomide-PEG3-C2-amine HCl; Pomalidomide-PEG(3)-NH2 hydrochloride; Pomalidomide-PEG3-NH2 HCl; Pomalidomide-3PEG-amine HCl
EINECS	Contact for details

Quality Control

Our Pomalidomide-Peg3-Nh2 Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring traceability and documentation for pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.