Description

Erythromycin-13C,D3 is a stable isotope-labeled analog of the macrolide antibiotic Erythromycin, specifically enriched with carbon-13 and deuterium. This compound is essential as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in pharmacokinetic and bioanalytical studies. It is a critical tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring precise measurement of Erythromycin and its metabolites.

Application

• Quantitative Bioanalysis: Serves as an internal standard in LC-MS/MS and GC-MS methods for the accurate quantification of Erythromycin in biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Used to study metabolic pathways and identify metabolites without interference from endogenous compounds.
• Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with GLP and FDA/EMA guidelines.
• Forensic and Doping Control Analysis: Provides definitive identification and quantification in forensic toxicology and anti-doping programs.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in analytical procedures to ensure the consistency and purity of Erythromycin-based drug products.

Basic Information

Product Name	Erythromycin-13C,D3
CAS No.	2378755-50-9
Molecular Formula	C37H6413C1D3NO13 *
Molecular Weight	~ 738.0 g/mol *
Synonyms	Erythromycin-13C,d3; (3R*,4S*,5S*,6R*,7R*,9R*,11R*,12R*,13S*,14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione-13C,d3; Erythromycin A-13C,D3; Isotopically Labeled Erythromycin; [13C,D3]-Erythromycin; ERY-13C,D3
EINECS	Contact for details

* Formula and Molecular Weight are representative. Exact values depend on the position and number of labeled atoms. Contact us for the certificate of analysis with precise specifications.

Quality Control

Every batch of Erythromycin-13C,D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity through advanced analytical techniques including NMR, HPLC, and High-Resolution Mass Spectrometry (HRMS). A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, isotopic enrichment, and analytical results. Our quality commitment supports research requiring traceable and reliable reference standards for regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.