Description

K-Ras Ligand-Linker Conjugate 4 is a sophisticated chemical entity designed for targeted drug discovery and development. This conjugate is of critical importance in the field of oncology research, specifically for the development of novel therapeutic agents targeting the notoriously difficult-to-drug K-Ras protein, a key driver in many cancers. It is an essential intermediate for pharmaceutical R&D teams and CROs engaged in creating PROTACs (Proteolysis Targeting Chimeras), molecular glues, and other advanced targeted protein degradation modalities.

Application

• PROTAC Development: Serves as a key building block for synthesizing heterobifunctional degraders targeting mutant K-Ras proteins (e.g., G12C, G12D).
• Chemical Biology Research: Used as a tool compound to study K-Ras signaling pathways, protein-protein interactions, and degradation mechanisms.
• Preclinical Candidate Synthesis: An advanced intermediate in the synthesis of potential drug candidates for oncology pipelines.
• Bioconjugation: Facilitates the creation of antibody-drug conjugates (ADCs) or other targeted delivery systems where a K-Ras ligand is required.
• High-Throughput Screening (HTS): Can be utilized in screening assays to identify and optimize novel K-Ras binders and degraders.

Basic Information

Product Name	K-Ras Ligand-Linker Conjugate 4
CAS No.	2378261-83-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KRAS Ligand-Linker Conjugate 4; K-Ras Degrader Conjugate 4; K-Ras Targeting Conjugate 4; PROTAC Intermediate for K-Ras; (S,R,S)-AHPC-PEG3-C6-amido-C4-acid (common linker-ligand component); VHL Ligand Linker Conjugate for K-Ras; E3 Ligase Ligand-Linker for K-Ras Degradation
EINECS	Contact for details

Quality Control

Every batch of K-Ras Ligand-Linker Conjugate 4 is manufactured and analyzed under strict quality protocols to ensure consistency and reliability for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Comprehensive analytical data, including HPLC purity, MS, and NMR, are provided. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under desiccated conditions. Allow the product to warm to room temperature in a dry environment before opening to prevent moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.